Principal Scientist – Immunology Biomarker Lead

About the role

We are seeking an accomplished and highly motivated Principal Scientist (Director) to serve as an Immunology Biomarker Lead within Translational Clinical Biomarkers. This role provides strategic and scientific leadership in designing, executing, analyzing, and communicating clinical biomarker strategies to support the immunology clinical development portfolio.

Key responsibilities

• Lead integrated biomarker strategies across discovery, early‑ and late‑stage clinical programs, ensuring clear hypotheses and fit‑for‑purpose endpoints.
• Represent biomarker strategy in cross‑functional program teams and governance forums, addressing mission‑critical questions.
• Translate disease biology and therapeutic mechanisms into actionable biomarker approaches for proof of biology, pharmacodynamics, and precision‑medicine endpoints.
• Drive selection and application of innovative biomarker technologies aligned with clinical utility.
• Lead biomarker sub‑teams and collaborate with discovery, translational, regulatory, biostatistics, and data science groups.
• Champion biomarker analysis plans, interpret complex datasets, and communicate insights to internal and external scientific audiences.

Required profile

• PhD or MD in Immunology, Biology or related STEM field with 7+ years (or equivalent experience) in immunology.
• Deep expertise in immune‑mediated/inflammatory diseases such as rheumatology, gastrointestinal inflammation, or dermatology.
• Proven track record of driving translational strategies that inform clinical development decisions.
• Demonstrated ability to lead highly matrixed, cross‑functional teams.
• Strong analytical, problem‑solving and communication skills.

Required skills

• Biomarker development, discovery, qualification and identification.
• Biostatistics and advanced data analytics.
• Bioinformatics.
• Precision‑medicine strategies.
• Omics technologies.

What we offer

• Salary range $190,800 – $300,300 per year.
• Eligibility for annual bonus and long‑term incentive.
• Comprehensive medical, dental, vision and other insurance benefits for employee and family.
• Retirement benefits including 401(k) plan.
• Paid holidays, vacation, compassionate and sick days.