Senior Principal Scientist, Quantitative Biosciences

About the role

Merck (MSD) is seeking a Senior Principal Scientist to lead the mass spectrometry capability within the Quantitative Biosciences group in Boston. The role combines deep technical expertise with strategic leadership to drive discovery programs.

Key responsibilities

• Lead the Boston mass spectrometry group supporting in‑vitro and in‑vivo pharmacology and serve as a scientific partner to discovery teams.
• Shape strategy for mass‑spectrometry‑enabled assay development, experimental design, data interpretation and quantitative pharmacology across programs.
• Partner with multidisciplinary teams to develop assays that inform mechanism, potency, selectivity, exposure‑response and translational decisions.
• Mentor and develop scientists, providing technical guidance and constructive scientific challenge.

Required profile

• Ph.D. (or equivalent) in biology, pharmacology, analytical chemistry, biochemistry, pharmaceutical sciences or related STEM field.
• 12+ years of relevant experience in pharma/biotech (or 15+ years with MS, or BS with 16+ years).
• Proven scientific leadership with impact on discovery programs, publications or platform advancement.
• Excellent communication skills and ability to influence cross‑functional teams.

Required skills

• Mass spectrometry‑based assay development
• Quantitative pharmacology
• In‑vitro pharmacology
• In‑vivo pharmacology
• Hit‑to‑lead and lead optimization

What we offer

• Salary range $214,100 – $337,000 per year
• Annual bonus and long‑term incentive eligibility
• Comprehensive medical, dental, vision, retirement and paid time‑off benefits