Site HSE Manager

About the role

The Site HSE Manager supports the expansion of the Durham campus to include Large Molecule (LMO) drug substance production at a new facility in RTP, NC. The role develops, implements and tracks HSE deliverables such as design input, construction safety and operational readiness before start-up, and acts as the functional lead for occupational safety across the campus's Gene Therapy/LMO/ADP operations. It sits on the LMO Steering Team and serves as its primary HSE advisor.

Key responsibilities

• Lead the design and implementation of HSE programs and controls for a safe, compliant start-up of LMO production.
• Integrate LMO-specific HSE requirements into site-wide processes, systems and training.
• Partner with internal teams and external providers on construction and operational safety.
• Advise on risk management, regulatory compliance and transparent reporting.
• Lead Process Safety, Electrical Safety, Fire Protection and Emergency Response programs.
• Establish and monitor HSE metrics and KPIs, and build site capabilities through training and safety governance.
• Ensure risk assessments, hazard analyses and technical evaluations for new operations, equipment and materials.
• Lead audits, investigations, regulatory interactions and continuous improvement.

Required profile

• 8+ years of HSE program development and management in a manufacturing or laboratory environment, preferably biopharmaceutical.
• Bachelor's or Master's degree in Occupational Health & Safety, Environmental Science, Engineering, Biology or a related field.
• Prior experience supporting the design and startup of new LMO/ADP facilities (PHAs, P&ID/design reviews, operational readiness) highly desired.
• Professional HSE certification (CSP, CIH or equivalent) highly desired.

Required skills

• HSE management systems and regulatory compliance
• Risk assessment and management
• Good Manufacturing Practices (GMP)
• Occupational hygiene and incident investigation and reporting

What we offer

• Expected salary of $114,100 to $211,900 per year, with a performance-based cash incentive and possible annual equity awards.
• Health, life and disability benefits, 401(k) with company contribution and match.
• Vacation, personal days, holidays and other leaves.