Senior Scientist, Mass Spectrometry Proteomics

About the role

Amgen is seeking a Senior Scientist in mass spectrometry-based proteomics to join its team in Thousand Oaks, CA. The role delivers insights that support target identification and drug discovery, and advances proteomics platform technologies through high-throughput proteomics approaches, including automated sample preparation and LC-MS/MS analysis.

Key responsibilities

• Design, develop and optimize high-throughput mass spectrometry-based proteomics workflows and screening platforms to accelerate drug discovery.
• Execute automated sample preparation and LC-MS/MS analysis across a broad range of high-throughput proteomics assays.
• Collaborate with chemistry, biology and disease area teams as a technical and scientific subject matter expert.
• Analyze data to generate insights on mechanism of action, target engagement and selectivity.
• Present research findings internally and externally and communicate plans, results and analyses to cross-functional teams.
• Maintain accurate documentation of experiments, protocols and analyses.

Required profile

• Basic qualification: PhD, PharmD or MD with relevant experience, OR Master's degree with 4 years of directly related experience, OR Bachelor's degree with 6 years of directly related experience.
• Preferred: doctorate in proteomics, chemoproteomics, biochemistry, chemistry or a related discipline.
• Preferred: 3+ years of experience in biotech or pharmaceuticals, and a track record of assay, method or platform development.
• Preferred: knowledge of targeted protein degradation or E3 ligase biology.

Required skills

• Hands-on operation and troubleshooting of high-throughput mass spectrometry systems.
• Preferred: strong quantitative and computational expertise in high-dimensional proteomics data analysis.
• Preferred: experience with sample preparation miniaturization and automation platforms.

What we offer

• Expected annual salary range of $127,121.75 to $171,988.25, varying with skills, experience and qualifications.
• Health, dental and vision coverage, life and disability insurance, and a retirement savings plan with company contributions.
• Discretionary annual bonus or sales-based incentive plan, stock-based long-term incentives, and flexible work models where possible.