Scientific Associate Director, Human Disease Biology, Inflammation Research

About the role

Amgen is looking for a Scientific Associate Director to lead human disease biology research in inflammation, working at the intersection of disease biology, multi-omic profiling, computational analysis and drug discovery. The role focuses on respiratory, dermatologic and/or rheumatologic diseases and requires deep expertise in human disease biology and experience turning discoveries into therapeutic hypotheses and drug discovery programs.

Key responsibilities

• Develop and run a disease-focused discovery strategy using multi-omic and human data to deepen mechanistic understanding of respiratory, dermatologic or rheumatologic diseases.
• Lead cross-functional initiatives integrating human genetics, single-cell biology, spatial biology, proteomics and computational analyses to identify and validate first-in-class targets, patient segments and biomarkers.
• Drive generation and interpretation of multimodal datasets and turn findings into actionable hypotheses for target discovery and program prioritization.
• Partner with computational biology, translational sciences, human genetics, pathology and disease-area biology teams to build integrated disease models.
• Design and oversee internal and external collaborations with academic investigators, clinical researchers, consortia and technology partners.
• Mentor scientists and foster rigorous, collaborative scientific practice across project teams.
• Influence the direction of several discovery programs and contribute to departmental strategy on human biology and technology deployment.

Required profile

• Basic: doctorate (PhD, ORP, or MD) and 4 years of relevant scientific experience, or master's degree and 7 years, or bachelor's degree and 9 years.
• Preferred: significant experience in both academic research and biopharmaceutical drug discovery.
• Preferred: record of scientific achievement such as high-impact publications, presentations, patents or external collaborations.
• Excellent communication skills and ability to influence scientific strategy across diverse stakeholders.

Required skills

• Integration of human genetics, transcriptomics, proteomics, single-cell, spatial, imaging and clinical datasets.
• Strong understanding of the drug discovery and development process, including target identification, validation, translational strategy and preclinical development.
• Ability to lead matrixed teams and build collaborations across scientific disciplines.

What we offer

• A competitive annual salary range (posted separately for the U.S., excluding Puerto Rico).
• Health, dental and vision coverage, life and disability insurance, and a retirement savings plan with company contributions.
• Discretionary annual bonus or sales-based incentive plan, stock-based long-term incentives and flexible work models where possible.