Principal Scientist – Translational Clinical Biomarkers

About the role

We are seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker leadership across programs within the Neuroscience portfolio. The role will lead the design, execution, analysis, and communication of translational and clinical biomarker strategies from early through late clinical development.

Key responsibilities

• Develop and lead integrated biomarker strategies across Neuroscience programs.
• Translate disease biology and therapeutic mechanism into clear translational hypotheses and fit‑for‑purpose biomarker approaches.
• Define how biomarkers inform development questions such as proof of biology, target engagement, dose selection, patient stratification, and go/no‑go decisions.
• Serve as biomarker representative on cross‑functional program teams and provide strategic input.
• Partner with Discovery, Clinical Development, Quantitative Sciences, Regulatory, Data Science, Clinical Operations and others to develop integrated translational strategies.
• Lead interpretation of biomarker and clinical datasets and translate findings into actionable recommendations.
• Identify opportunities to understand disease heterogeneity, therapeutic response, resistance and biological drivers of outcomes.
• Evaluate emerging biomarker technologies and analytical approaches for relevance to development questions.

Required profile

• Ph.D., M.D. or equivalent with 10+ years of experience in neuroscience, translational medicine or biomarker science.
• Significant experience developing and executing translational or clinical biomarker strategies in drug development.
• Scientific expertise in neuroscience, neurodegeneration, psychiatric or related disorders.
• Proven ability to translate scientific hypotheses into biomarker strategies that inform clinical decisions.
• Strong analytical and problem‑solving skills with experience synthesizing complex datasets.
• Excellent written and verbal communication skills and ability to influence cross‑functional teams.

Required skills

• Biostatistics
• Bioinformatics
• Quantitative sciences
• Multidimensional biomarker data analysis

What we offer

• Salary range $173,200 – $272,600 per year.
• Eligibility for annual bonus and long‑term incentive.
• Comprehensive benefits package including medical, dental and vision coverage.