Translational Medicine Director/Associate - Cardiovascular & Metabolic

About the role

Novartis BioMedical Research (BR) is looking for a Translational Medicine Director/Associate for its Cardiovascular Metabolism (CVM) group in Cambridge, USA. The role works with the CVM TM Head and other experienced TM experts to build high-value decision strategies for the translational medicine component of drug development projects and to lead global cross-functional project teams through the proof-of-concept (PoC) phase and beyond. It is a dual-level posting (Associate Director or Director) whose exact level depends on the candidate's skills and experience.

Key responsibilities

• Lead global project teams through the PoC phase and drive implementation of the PoC strategy, taking part in project teams from NTRC through to registration
• Own the clinical portion of the Integrated Development Plan (IDP) through PoC
• Act as medical monitor for one or more clinical studies
• Communicate clinical team matters to project teams and decision boards such as the Disease Area Decision Board, and convene internal and external leaders to discuss the proposed PoC approach
• Evaluate clinical centers and foster communication with collaborating investigators
• Oversee publication and external presentation of PoC study results
• Be accountable for compound-related biomarker strategies and work with biomarker experts on their implementation
• Help research scientists define and run a strategy for preclinical support, including assessment of medical need, clinical development pathway proposals and review of preclinical data
• Take part in team presentations to Health Authorities as TM Expert

Required profile

• Doctoral degree; MD required, with clinical subspecialty training preferred in cardiovascular disease or endocrinology/metabolic disease
• At least 1-2 years' experience in a pharma/biotech company, CRO or academic medical center (5+ years for Director level)
• Recognized medical and scientific expertise, with a record of high-quality publications in international journals
• Fluent oral and written English
• Able to work independently on study planning and execution, and to lead multidisciplinary teams in a matrix organization
• Additional consideration for advanced research experience in data science, genetics/genomics, AI in clinical research or digital/wearable health science

Required skills

• Clinical trials and clinical operations
• Data analysis and data monitoring
• Drug development and drug discovery process
• Excellent written and oral communication and presentation skills

What we offer

• Expected salary range of $248,500 to $461,500 per year, depending on level and experience
• Performance-based cash incentive and possible eligibility for annual equity awards
• Benefits package including health, life and disability coverage, 401(k) with company contribution and match, and time off including vacation, personal days and holidays