Senior Scientist, In Vivo Comparative Medicine

About the role

Novartis Research Collaborations (RC) in Comparative Medicine, part of In Vivo Science & Technology, is looking for a Senior Scientist I or II to join its team in Cambridge, MA. The role provides scientific leadership and hands-on expertise to design, run, analyze and interpret complex in vivo studies across multiple therapeutic modalities, supporting the xRNA/siRNA portfolio, a global PK/PD capability and surgical model capabilities. It works closely with Biomedical Research project teams to generate efficacy, PK/PD, biodistribution, phenotyping and mechanistic datasets.

Key responsibilities

• Partner with project teams to define scientific questions, study objectives and decision criteria
• Lead the design, execution, analysis and interpretation of in vivo studies for small molecules and biologics, including antibodies and xRNA
• Develop and apply disease-relevant models and generate efficacy, PK/PD and mechanistic datasets
• Analyze data with statistical and computational approaches and build digital workflows
• Mentor colleagues and support resource planning across a portfolio of studies
• Uphold scientific integrity, animal welfare and compliance with the 3Rs

Required profile

• Bachelor's or Master's degree in Biomedical Sciences, Pharmacology, Physiology, Comparative Medicine or a related field; recent PhD graduates (within 3 years) considered
• 5+ years of experience in laboratory animal research, in vivo pharmacology, translational research or drug discovery
• Extensive experience designing, running and interpreting in vivo pharmacology studies
• Strong expertise in efficacy, mechanism-of-action, translational pharmacology, PK/PD and model development
• Ability to work in a matrixed research environment

Required skills

• Data analysis and visualization with R, Python or comparable tools
• Preferred: phenotyping platforms, surgical models (EEG, intracranial injection, ventricular cannulation), siRNA and imaging experience

What we offer

• Salary of $98,700-$183,300 for Senior Scientist I and $103,600-$192,400 for Senior Scientist II
• Performance-based cash incentive and possible annual equity awards
• Health, life and disability benefits, 401(k) with company match, and time off