Senior Principal Scientist, Translational Profiling Imaging

About the role

Novartis is looking for a highly motivated scientist to lead a small group of biologists with advanced imaging expertise in the Translational Profiling group of Discovery Sciences, Biomedical Research. The role sits in the imaging team in Cambridge, MA, and drives the integration of new spatial proteomics and imaging technologies across matrix teams to support target discovery and validation across disease areas. It is an internal job titled Senior Principal Scientist / Associate Director, and is an onsite position.

Key responsibilities

• Lead the development and application of translational biology, imaging and profiling strategies across the drug discovery pipeline.
• Design, develop and implement novel assays and integrated workflows using imaging, spatial biology, proteomics and complementary technologies.
• Maintain an active hands-on presence: experimental design, assay development, troubleshooting and interpretation of complex datasets.
• Generate biological insights on disease mechanisms, therapeutic mechanisms of action, tissue targeting, pharmacology and translational biomarkers.
• Lead cross-functional matrix teams and collaborate with project teams, platform scientists and disease-area researchers.
• Shape the strategy and evolution of imaging, spatial biology and translational profiling capabilities.
• Establish and manage external collaborations to evaluate emerging technologies.
• Mentor scientists and communicate findings and recommendations to project teams, research leaders and senior stakeholders.

Required profile

• Ph.D. in Biology, Cell and Molecular Biology or a related life sciences discipline, with 7+ years of postgraduate experience in drug discovery.
• Strong expertise in experimental biology, including cellular and tissue-based models, with hands-on experience in confocal, super-resolution and other advanced microscopy.
• Proven track record applying imaging and translational biology approaches across multiple disease areas.
• Demonstrated scientific leadership, including mentoring and influencing cross-functional teams in a matrixed research environment.
• Preferred: experience integrating imaging and multi-omics approaches, and target and drug discovery experience in an industry setting.

Required skills

• Advanced microscopy (confocal, super-resolution)
• Imaging and spatial biology
• Translational profiling and proteomics
• AI-enabled approaches for imaging, omics and multidimensional data analysis

What we offer

• Expected salary of $138,600-$257,400 for Senior Principal Scientist and $152,600-$283,400 for Associate Director, depending on skills and experience.
• Performance-based cash incentive and possible annual equity awards.
• Health, life and disability benefits, 401(k) with company contribution and match, and a time-off package including vacation, personal days and holidays.