Research Scientist I or II, Oligonucleotide Chemistry

About the role

Novartis is looking for a Research Scientist I or II in Oligonucleotide Chemistry in its xRNA therapeutics program in Cambridge, USA. You will synthesize, optimize and characterize therapeutic oligonucleotides and collaborate with a diverse team across discovery and development. Relocation support is not offered, so only apply if you can access the role.

Key responsibilities

• Execute solid-phase synthesis of research-scale oligonucleotides using advanced automated DNA and RNA synthesizers.
• Purify, desalt and characterize oligonucleotides using chromatographic and mass spectrometry techniques.
• Develop and optimize synthesis, purification and analytical methods to improve performance and reproducibility.
• Operate, maintain and troubleshoot laboratory instrumentation supporting oligonucleotide production and analysis.
• Prepare and maintain standard operating procedures for consistent laboratory practice.
• Organize, analyze and document experimental results using electronic laboratory notebook systems.

Required profile

• Bachelor of Science or Master of Science in Chemistry or a related scientific discipline.
• One to three years of laboratory experience in academic or industrial research environments.
• Hands-on experience with automated solid-phase synthesizers and therapeutic oligonucleotide synthesis workflows.
• Understanding of RNA therapeutics and their application in biological systems.
• Strong collaboration, adaptability and self-motivation in a fast-paced scientific environment.

Required skills

• Purification, characterization and analysis of oligonucleotides using chromatography and mass spectrometry.
• Desirable: experience supporting oligonucleotide process development, optimization or technology innovation.
• Desirable: excellent scientific communication and the ability to present findings to multidisciplinary teams.

What we offer

• Annual base salary range of USD 66,800 to 124,000, with a possible performance-based bonus.
• Benefits such as insurance plans, retirement plans and wellbeing resources.
• Flexible and hybrid working options where possible, and a minimum of 14 weeks paid parental leave.