Principal Scientist I/II, Oligonucleotide Chemistry & Innovation

About the role

Novartis is looking for a Principal Scientist I or II in Oligonucleotide Chemistry and Innovation in Cambridge, USA, to build and advance its xRNA therapeutic platform. You will lead the development of novel oligonucleotide chemistries and help shape the future of RNA medicines, working alongside a team of scientists in a fast-paced research environment. Relocation support is available.

Key responsibilities

• Lead synthesis, purification, characterization and analysis of chemically modified oligonucleotides and conjugates.
• Design and optimize novel oligonucleotide chemistries through structure-activity relationship studies.
• Develop and implement robust synthetic routes for preclinical RNA therapeutic candidates.
• Drive cross-functional collaboration to advance oligonucleotide programs from discovery through preclinical stages.
• Mentor scientists and improve laboratory workflows for efficiency, quality and innovation.
• Establish and maintain standard operating procedures for reproducible oligonucleotide manufacturing.
• Operate, troubleshoot and maintain analytical and synthesis instrumentation, including HPLC and LC-MS.

Required profile

• PhD in Chemistry or a related scientific discipline.
• At least five years of experience synthesizing therapeutic oligonucleotides in an industry or research setting.
• Deep expertise in solid-phase oligonucleotide synthesis, deprotection, purification and characterization.
• Proven experience developing and optimizing oligonucleotide chemistries and conjugates.
• Understanding of RNA therapeutics, including siRNA and antisense oligonucleotides.
• Excellent collaboration and communication skills across multidisciplinary teams.

Required skills

• Strong knowledge of phosphoramidite chemistry and modern synthetic chemistry techniques.
• Hands-on experience with automated oligonucleotide synthesizers and analytical instrumentation.
• Analytical chemistry, chemical synthesis and medicinal chemistry.

What we offer

• Base salary range of USD 108,500 to 201,500 per year, with a possible performance-based bonus.
• Benefits such as insurance plans, retirement plans and wellbeing resources.
• Flexible and hybrid working options where possible, and at least 14 weeks of paid parental leave.