Postdoctoral Researcher RNA Biology and Therapeutics in Kidney Disease

About the role

The Aboudehen Laboratory at Stony Brook University seeks a highly motivated Postdoctoral Research Fellow to investigate RNA regulatory mechanisms and develop RNA‑based therapeutic strategies for autosomal dominant polycystic kidney disease (ADPKD).

Key responsibilities

• Investigate disease‑associated long non‑coding RNAs using mouse genetics, cell models, and RNA interaction assays.
• Study RNA‑binding proteins and regulatory RNAs that control PKD1 expression, mapping interactions and binding sites with eCLIP/CLIP‑based approaches.
• Validate therapeutic targets in genetically engineered mouse models of PKD and primary ADPKD cells.
• Develop RNA‑targeted therapeutic approaches, including antisense oligonucleotides.

Required profile

• PhD or equivalent in RNA biology, molecular biology, cell biology, genetics, biochemistry, biomedical sciences, or a related discipline.
• Strong molecular and cellular biology skills with a demonstrated ability to conduct independent research.
• Clear interest in RNA regulation and disease mechanisms.

Required skills

• eCLIP, iCLIP, CLIP‑seq or related RNA‑protein interaction mapping techniques.
• RNA‑targeting technologies such as siRNA and antisense oligonucleotides.
• Mouse genetics and in‑vivo disease modeling.
• Cell culture and molecular biology assays.