Sr. Scientist - Translational PBPK Modeling

About the role

The Drug Metabolism and Pharmacokinetics (DMPK) group at Genentech seeks a Ph.D.-level Senior Scientist to apply cutting-edge translational modeling approaches to small molecule drug discovery and development projects. Physiologically-based Pharmacokinetic (PBPK) modeling will be a key focus. The DMPK group works with medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, run preclinical studies and support IND and NDA filings.

Key responsibilities

• Strategize, plan, execute and report PBPK modeling and simulations independently
• Present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions and scientific conferences
• Represent DMPK on multi-functional discovery and development project teams
• Lead the DMPK strategy, including designing, executing and reporting non-clinical studies

Required profile

• Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences or a related field
• 2 years of relevant industry or post-doctoral experience in drug discovery/development
• Expertise in PBPK modeling and quantitative pharmacology
• Strong communication and organizational skills in cross-functional teams
• Preferred: prior pharmaceutical industry experience as a DMPK project leader; experience with diverse modalities (small/large molecules, peptides); experience with additional tools such as Phoenix, R, NONMEM, SimBiology and Python

What we offer

• Domestic relocation offered
• Expected salary range of 124,300 to 230,900 USD for the San Francisco area, depending on experience and qualifications
• A discretionary annual bonus may be available