Senior/Principal Scientist, Computational Neuroscience

About the role

Roche's Computational Sciences Center of Excellence (CS-CoE) is seeking a creative and accomplished scientist to develop and execute its Foundational Data and Models strategy in Computational Neuroscience. The role sits in the Computational Biology & Medicine department and aims to help deliver new treatments for neurodegenerative and neuroinflammatory diseases such as Alzheimer's, Parkinson's, ALS and multiple sclerosis. The work extends Roche's existing data ecosystems to accelerate the Neuroscience portfolio.

Key responsibilities

• Develop strategy to mine large data sets and drive science using LLMs, advanced automation and AI agents.
• Analyze and integrate human genetic, single-cell atlases, perturbation and other data to gain insight into the pathobiology of neurodegenerative and neuroinflammatory diseases.
• Nominate new entries to the Neuroscience department Target Assessment Portfolio and identify new biomarkers for existing therapeutic programs.
• Serve as computational lead on pipeline programs, supporting target validation, mechanism of action, safety and biomarker studies.

Required profile

• PhD or equivalent with in-depth training in a relevant field, and a deep understanding of biological pathways relevant to neurodegeneration/neuroimmunology and the computational methods used to study them (Senior Scientist).
• For Principal Scientist: successful postdoctoral research or at least 3 years of equivalent experience after the PhD.
• A track record of impactful scientific achievement, such as co-first or lead author publications.
• Excellent communication skills and proven success in complex, multidisciplinary environments.
• Onsite presence at the South San Francisco campus at least 3 days per week; relocation benefits are available.

Required skills

• Perturb-seq and related CRISPR screening
• Patient tissue or CSF/PBMC atlases
• Use of human genetics to prioritize drug targets
• Familiarity with AI approaches and AI agents for scientific insight

What we offer

• Salary range of $144,900-$269,100 (Senior Scientist) and $161,000-$299,000 (Principal Scientist), depending on experience, qualifications and location.
• A discretionary annual bonus based on individual and company performance.
• The position qualifies for the benefits described in the original listing.