Senior Scientist - Translational PKPD

About the role

Genentech is hiring a Senior Scientist in its translational Pharmacokinetics and Pharmacodynamics (tPKPD) department within the Development Sciences division of the Genentech Research and Early Development (gRED) unit. The role supports preclinical PKPD work that guides the design, delivery and development of biologics in the pipeline, working independently or under the direct supervision of a Scientist.

Key responsibilities

• Design, conduct, analyze and interpret in vitro and in vivo ADME and PKPD studies to understand drug candidate pharmacology in animals and predict human behavior.
• Prepare summary tables and reports for non-clinical studies, and documents for regulatory agencies such as INDs and BLAs under supervision.
• Present data at project teams, department meetings and conferences, and publish PKPD-focused research in scientific journals.
• Manage an active laboratory program supporting basic PKPD research and pipeline projects.
• Collaborate with Clinical Pharmacology, Research, Bioanalytical Sciences, Safety Assessment, PD Biomarker/OMNI, Antibody Engineering, Non-clinical Biostatistics, Regulatory Affairs and others.
• Take part in compliance and safety activities and perform other assigned duties.

Required profile

• Ph.D., M.D. or PharmD, or equivalent curriculum in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology or related fields.
• 1-2 years of relevant industry experience in translational PKPD/pharmacology; postdoctoral experience preferred.
• Strong record of accomplishments shown through co-authored publications, patents, internal reports and/or regulatory filings.
• Demonstrated independent thought and ability to design, carry out, analyze, interpret and document studies alone.
• Good communication skills and the ability to present independently.

Required skills

• Knowledge of laboratory techniques and safety; regular GLP and laboratory safety training required.
• Quantitative PKPD software such as WinNonlin, NONMEM, ADAPT II, Matlab, Simbiology or R.

What we offer

• Expected salary range of $120,700-$224,100 per year, depending on experience, qualifications and location; a discretionary annual bonus may be available.
• The position does not qualify for relocation benefits.