Senior Scientist, Drug Metabolism & Pharmacokinetics

About the role

The Drug Metabolism & Pharmacokinetics (DMPK) department at Genentech is looking for a highly motivated leader to support small molecule projects in discovery and development. The DMPK group helps bring safe and effective medicines to market by studying the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule and emerging modality drug candidates, working closely with medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory. The person selected will lead the DMPK strategy, design and oversee non-clinical studies in a collaborative project team.

Key responsibilities

• Serve as the DMPK representative on multidisciplinary project teams and communicate recommendations to them.
• Lead DMPK strategy and author or review sections of regulatory briefing packages and filings.
• Design, oversee, interpret and integrate in vitro and in vivo ADME, PK studies, and translate nonclinical data into human PK and dose predictions.
• Identify DMPK-related risks and develop mitigation strategies.

Required profile

• PhD in pharmacokinetics, drug metabolism, pharmaceutical sciences or a related discipline.
• At least 2 years of relevant pharmaceutical industry experience as a DMPK project leader.
• Strong knowledge of ADME, PK and the use of DMPK data in discovery and development decisions.
• Ability to explain complex scientific data, uncertainties and recommendations clearly to multidisciplinary teams and senior stakeholders.
• Preferred: experience leading multi-functional teams across diverse modalities (small/large molecules, peptides, degraders, conjugates), especially outside Lipinski's Rule-of-5, and experience through candidate selection, IND-enabling development, clinical development or regulatory interactions.

Required skills

• Hands-on experience with PK/PD modeling and/or PBPK modeling using modeling and simulation platforms is highly desired.

What we offer

• Domestic relocation is offered.
• Expected salary range of 124,300 to 230,900 USD for the San Francisco area, depending on experience and qualifications; a discretionary annual bonus may be available.