Scientist, Pathology

About the role

Amgen is seeking a Scientist to join its Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) department in South San Francisco, California. The Scientist develops and applies tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy and biomarker discovery.

Key responsibilities

• Develop, optimize, validate and standardize histopathology assays using FFPE samples, including single-plex and multiplex immunohistochemistry (IHC) and in situ hybridization (ISH) in colorimetric and immunofluorescent formats.
• Use imaging modalities and digital pathology tools to generate, analyze and interpret tissue-based data for target qualification, pharmacodynamic and efficacy assessments and biomarker development.
• Collaborate with pathologists, research investigators and translational teams to deliver data supporting mechanism-of-action studies, in vivo model development and toxicity assessments.
• Maintain clear documentation and share results through laboratory information systems, databases and team presentations.

Required profile

• Doctorate degree, or Master's degree with 2+ years of relevant research and industry experience, or Bachelor's degree with 4 years of relevant research and industry experience.
• Preferred: PhD or master's in cell biology, molecular biology or a related discipline, and two or more years of molecular pathology experience, preferably in industry.
• Ability to manage multiple projects and priorities at once, and strong written and verbal communication skills.

Required skills

• Pathology-based methods: IHC, multiplex IHC, ISH and immunofluorescence imaging.
• Digital pathology and image analysis, preferably with HALO and/or Visiopharm.
• Experience with automated staining platforms such as Ventana, Leica Bond or IntelliPATH is preferred.
• Experience analyzing pathology imaging data (H&E, IHC, multiplex immunofluorescence, and/or spatial transcriptomics).
• Familiarity with whole-slide imaging and understanding of machine-learning methods for image segmentation, classification, detection and representation learning are preferred.

What we offer

• Expected annual salary range of $129,404 to $175,076 USD, depending on skills, experience and qualifications.
• Health, dental and vision coverage, life and disability insurance, and a retirement savings plan with company contributions.
• Discretionary annual bonus or sales-based incentive plan, stock-based long-term incentives, flexible work models where possible, and time-off plans.