Scientist 3 - Translational Medicine

About the role

Genentech's Translational Medicine (TM) team supports its R&D portfolio of novel therapies across Ophthalmology, Metabolism, Neuroscience, Immunology and Infectious Diseases. The Scientist 3 joins the TM team on-site at the South San Francisco campus, partnering with cross-functional R&D teams to drive translational research for next-generation therapeutic targets and providing biomarker support for glaucoma neuroprotection programs. The role bridges data science and the wet lab.

Key responsibilities

• Analyze high-dimensional datasets (e.g., proteomics, transcriptomics) from clinical and preclinical samples to find therapeutic targets and candidate biomarkers.
• Design and run experiments using disease-relevant in vitro human cell models to turn data insights into functional biology.
• Lead and coordinate exploratory clinical studies with internal and external collaborators to advance translational research and discover clinical biomarkers.
• Work with Research Biology, Computational Sciences, Tissue Genomics & Proteomics, Biostatistics, Clinical Pharmacology and Bioanalytical Sciences.
• Develop and qualify custom assays (e.g., Simoa, NULISA) beyond standard commercial kits.
• Share insights through reports, presentations and peer-reviewed publications.

Required profile

• PhD in Biological Sciences (neuroscience, immunology, cell biology or related); candidates without a PhD but with equivalent rigorous scientific experience are also encouraged to apply.
• Clinical or translational experience in retinal biology is preferred but not required.
• Proven track record of wet-lab work and bioinformatic analysis, with a strong peer-reviewed publication record.
• Scientific independence, teamwork, curiosity and clear communication.

Required skills

• Wet-lab techniques: cell culture, ELISA, qPCR, NGS/transcriptomics.
• Programming in R or Python for biostatistics and bioinformatics on high-dimensional datasets.

What we offer

• Expected salary range of $100,400 - $186,400 for California, depending on experience and qualifications; a discretionary annual bonus may be available.
• The position qualifies for the benefits described in the original posting.
• No relocation benefits are available.