Scientist 3, Biochemical and Cellular Pharmacology

About the role

Genentech's Biochemical and Cellular Pharmacology department is looking for a Scientist 3 to join its cardio-metabolic therapeutics program. The role supports the selection and characterization of drug candidates, developing and running biochemical and cell-based assays in heterologous and physiologically relevant systems to evaluate drugs in cardiovascular, renal and metabolic areas, from lead finding through optimization.

Key responsibilities

• Design and run experiments independently, troubleshoot issues, analyze complex data with advanced computational tools and document results
• Drive screening across multiple projects with a broad set of functional assays and technologies
• Pioneer novel assay platforms for receptor pharmacology and mechanism of action, reviewing the literature to guide them
• Use laboratory robotics (Bravo, Tecan, Echo) to automate and speed up workflows
• Work with multidisciplinary teams, present findings and communicate results to stakeholders

Required profile

• Bachelor's or Master's degree in Cell Biology, Pharmacology, Biochemistry or a related field
• 8+ years of hands-on research experience in fast-paced pharma or biotech settings
• Strong problem-solving ability, scientific rigor, organization and good time management
• Excellent written and verbal communication skills

Required skills

• Culturing and assaying mammalian and primary cells (including cardiomyocytes), stable cell line generation and gene editing such as CRISPR
• Knowledge of GPCR signaling, ligand-receptor binding kinetics and pharmacological characterization
• Microplate biochemical and cellular assays (HTRF, AlphaScreen, luminescence)
• Preferred: cardiovascular, renal or metabolic disease expertise, flow cytometry, ELISA, high-content image analysis, lab automation and high-throughput screening, and data tools such as GraphPad Prism, Genedata, Excel, Python or R

What we offer

• Onsite position in South San Francisco, CA, eligible for relocation assistance
• Expected salary range of $103,400 to $192,000 per year, depending on experience and qualifications
• A possible discretionary annual bonus based on individual and company performance