Scientific Manager, Translational Biology, CVRM

About the role

The Cardiovascular, Renal and Metabolism (CVRM) Translational Biology group within Genentech Research and Early Development is looking for a Scientific Manager to lead pharmacology efforts that drive drug discovery and therapeutic development. You will design and run mechanistic studies to characterise compounds and their effects on physiology and pathophysiology, evaluate literature and novel assays, and work closely with scientists in a multidisciplinary team.

Key responsibilities

• Provide hands-on scientific and technical support for in vivo and ex vivo studies in animal models of cardiovascular, renal, obesity and metabolic conditions, moving novel drug candidates toward clinical development.
• Plan and run experiments, develop and follow protocols, document data, troubleshoot, interpret results and communicate findings.
• Advise on technical or project strategy and mentor and train junior researchers.
• Manage studies performed at CROs, evaluate the data, develop technical documents and help prepare or review information for regulatory submissions.
• Work in multidisciplinary teams and share lab activities, timelines and results with colleagues and collaborators.

Required profile

• PhD in Pharmacology, Biology or a related field with 3+ years of relevant post-graduate experience.
• Strong in vivo background in the cardio-metabolic disease field.
• Hands-on experience with cardiovascular models (heart and kidney ischaemia-reperfusion injury, transverse aortic constriction) and phenotyping (echocardiography, heart catheterization).
• Ability to multitask across several projects and to solve problems creatively.
• Good interpersonal skills and ability to communicate in cross-functional settings.
• Preferred: rodent surgery, ex vivo experiments and primary cell isolation; biotech/pharma experience; relocation benefits available.

What we offer

• Expected salary range of $115,900 to $215,300 depending on experience, qualifications and location.
• A possible discretionary annual bonus based on individual and company performance.
• Benefits package and relocation benefits for this posting.