Process Development Scientist - Peptide & Oligonucleotide

About the role

PolyPeptide is seeking a Process Development Scientist in Torrance, CA, to support the design, execution, optimization and scale-up of synthetic processes for peptide and/or oligonucleotide API development. The role bridges the gap between laboratory development and manufacturing, helping develop robust, efficient and cost-effective processes that support clinical and commercial manufacturing.

Key responsibilities

• Plan and coordinate technology transfer from Development to Production, onsite and across sites
• Design, execute and optimize synthetic processes for peptide and/or oligonucleotide API development
• Perform intermediate chemical processing steps following established safety and process procedures
• Check reactor systems against SOPs and operating manuals, monitor reactions and prepare solutions for purification
• Purify crude peptide using HPLC under minimal supervision and conduct lyophilization and drying
• Run in-process checks of fractions with analytical HPLC and report results
• Support troubleshooting, identify and report deviations and equipment concerns, and maintain safety, housekeeping and cleanliness standards
• Support cross-functional project teams and perform additional duties as needed

Required profile

• Ph.D. in Chemistry, Chemical Engineering or a related discipline with at least 1 year of relevant experience, or a Master's degree with at least 5 years of relevant experience
• Experience with organic chemistry; peptide chemistry and downstream purification preferred
• Ability to interpret analytical results and work independently while collaborating with multidisciplinary teams
• Preferred: experience with peptide, oligonucleotide or API development, HPLC purification, lyophilization, scale-up and technology transfer, and familiarity with cGMP requirements

Required skills

• Synthetic organic chemistry, process development and analytical techniques
• HPLC purification and analytical HPLC
• Lyophilization and drying processes
• Strong analytical thinking, problem-solving and communication skills

Salary: $90K - $115K.