Principal Scientist - Cell Therapy Process Development

About the role

Genentech, a member of the Roche group, is hiring a Technical Development Principal Scientist for its Cell Therapy Process Development team within the Pharma Technical Cell and Gene Therapy Development (PTCC) organization. The role leads cell culture experiments and process development for a diverse portfolio of cell therapy products, working with stakeholders inside and outside PTCC/PTC and establishing highly productive, next-generation processes.

Key responsibilities

• Design and run cell culture experiments to understand cell biology, process consistency and raw material impacts
• Apply advanced technologies to improve cell culture performance and build next-generation platform processes
• Lead technology transfer and work with cross-functional teams to develop robust cell-based therapies
• Provide technical leadership to product teams, media preparation operations, raw material assessments and supply chain partners
• Cultivate a lean mindset focused on simplification and continuous improvement
• Interface with the Cell Therapy Process Development department, PTC, other Genentech/Roche organizations and external collaborators
• Build thought leadership through peer-reviewed publications, conference presentations and scientific meetings

Required profile

• BS, MS or PhD in biological sciences, chemical engineering or a related discipline, with 5+ years of experience in process development and cell culture techniques
• Proven ability to lead technical projects to completion and foster an inclusive, collaborative team
• Strong matrixed stakeholder management and influence across organizational boundaries
• Excellent verbal and written communication, shown through presentations and publications

Required skills

• Cell culture techniques and process development
• Preferred: expertise in culture, expansion and functional assessment of hESCs, iPSCs, MSCs and RPEs
• Preferred: bioreactor process development, including process control strategies, P&ID requirements and set-points for stirred-tank bioreactors
• Preferred: experience scaling up adherent cell lines in suspension

What we offer

• Expected salary range of $120,800 - $224,300 for the California location, depending on experience and qualifications
• A discretionary annual bonus may be available
• The position qualifies for the benefits described in the original listing
• Relocation benefits are not available for this posting