Principal Scientist and Group Leader, Antibody Engineering

About the role

Genentech's Department of Antibody Engineering is looking for a Principal Scientist to lead a high-impact laboratory team focused on biotherapeutic innovation. The role develops molecular formats that bridge molecular developability with optimized biological function, turning exploratory science into medicines for patients. It is an office-based position in South San Francisco, with relocation benefits available.

Key responsibilities

• Direct and manage a bench-focused laboratory team, fostering technical growth, innovative research and effective execution.
• Develop novel methods and predictive assays to de-risk emerging therapeutic formats.
• Define molecular requirements for therapeutic projects and lead cross-functional teams to identify and advance next-generation clinical candidates.
• Drive platform innovation across emerging biotherapeutic mechanisms, potentially including induced proximity, receptor agonism, targeted therapeutics or antibody-drug conjugates (ADCs).
• Cultivate an inclusive, high-performing lab culture built on curiosity, scientific rigor and open communication.
• Collaborate with partners in Discovery Biology, Structural Biology, Translational Science and Technical Development to integrate biological activity with clinical manufacturability.

Required profile

• PhD in biochemistry, chemical biology, structural biology or a related field; candidates with extensive prior experience or coming directly from postdoctoral positions are encouraged to apply.
• Demonstrated expertise in protein engineering and biology, with a track record of using innovative molecular engineering approaches to solve complex biological questions.
• Sustained productivity and scientific contributions, such as publications in top-tier peer-reviewed journals, issued patents and notable external presentations.
• Strong collaborative mindset and excellent written and verbal communication skills.

Required skills

• Protein engineering and protein biology
• Foundational understanding of protein stability and protein-protein interactions, and methods for characterizing them

What we offer

• Expected salary range of $141,500 to $262,900 USD, depending on experience, qualifications and location; a discretionary annual bonus may be available.
• Relocation benefits.