Associate Principal Scientist, Preclinical Research

About the role

Cabaletta Bio is looking for an experienced Associate Principal Scientist to report to the Vice President, Preclinical Research. The role is based in Philadelphia, PA, and focuses on discovery research as a molecular biology and gene delivery subject matter expert. You will collaborate across Cellular Immunology, Pharmacology, CMC and other departments to build a product pipeline and support preclinical IND-enabling studies, while leading a team that develops and runs molecular biological assays and reagents.

Key responsibilities

• Manage a team of employees who run R&D experiments, design and implement assays and support reagent production.
• Support new preclinical discovery projects by working with lab scientists to design and execute critical experiments.
• Oversee the planning, execution and interpretation of team laboratory work according to program timelines.
• Help identify the people, equipment, supplies and space needed to meet discovery goals.
• Work with cross-functional peers and senior management to set team objectives, share results and project status, and meet company objectives.
• Contribute to process improvements and the adoption of new technologies through your expertise in molecular biology and gene delivery.

Required profile

• PhD in Molecular Biology, Cell Biology or a similar field.
• At least 2 years of biotechnology industry experience.
• Strong leadership and management skills, with a track record of achievement and ability to work in cross-functional teams.
• Clear communication in writing and in scientific presentations.
• Flexibility to evaluate new technologies, possibly outside your current field, and to guide junior team members through their evaluation.

Required skills

• Demonstrated expertise in advanced molecular biology techniques, assay development and implementation.
• Experience with methods for gene delivery to primary T-cells such as lentiviral vectors, lipid nanoparticles and AAV.
• Preferred: prior management of direct reports in biotech, hands-on experience with lipid nanoparticles and viral vectors, startup biotech experience, and experience with in vivo CAR-T studies in murine and non-human primate models and IND-enabling studies.

What we offer

• Health and retirement benefits.
• PTO.
• Stock option plans.