Principal Scientist - Modeling & Simulation

About the role

Amgen is looking for a Principal Scientist in its Clinical Pharmacology, Modeling and Simulation department. The role supports clinical development and translational sciences programs across multiple therapeutic areas, building pharmacostatistical models to support population PK/PD and exposure-response analyses.

Key responsibilities

• Build pharmacostatistical models supporting population PK/PD and exposure-response analyses using state-of-the-art modeling and simulation techniques.
• Conduct binary and categorical data analyses, time-to-event (hazard) models, Poisson models, MCMC and Bayesian methods for exposure-response and population PK/PD analysis.
• Perform meta-analysis using proprietary and/or literature data.
• Take part in cross-functional project teams and give scientific input for dose selection and early and late study designs.
• Contribute to clinical pharmacology strategy and implement project plans.
• Generate modeling reports and contribute to summary documents for regulatory submissions.

Required profile

• Basic: PhD, PharmD or MD (with relevant post-doc where applicable) and 2 years of PK/PD or statistical modeling experience; or Master's degree and 5 years of PK/PD or statistical modeling experience; or Bachelor's degree and 7 years of PK/PD or statistical modeling experience.
• Preferred: PhD in pharmaceutical sciences, applied statistics/mathematics, bio-statistics or engineering, or equivalent professional degree, with 3 years of PK/PD or statistical modeling experience and 5+ years of industry or academic experience in pharmacometrics and/or applied bio-statistics of small molecules and/or biologics.

Required skills

• Proficiency in modeling software such as NONMEM, SAS, R/S-Plus, STAN and MATLAB.

What we offer

• Expected annual salary range of $143,526.75 to $194,183.25 in the U.S. (excluding Puerto Rico).
• Health, dental and vision coverage, life and disability insurance, and a retirement savings plan with company contributions.
• Discretionary annual bonus or sales-based incentive plan, stock-based long-term incentives, flexible work models where possible, and time-off plans.